Category Archives: Endocrine Disruptors

Dechlorination — how it works

In Science this week there is a paper by Brommer et al. from Berlin and Jena, Germany, who reports the structure of the enzyme dehalogenase from
Sulfurospirillum multivorans in complex with trichlorethane and a pseudo-vitamine B12 providing the cobalt ion for electron transfer. A Perspectives article by E.A. Edwards further explains the findings: the pseudo-vitamine B12 is protected from the outside by the dehalogenase and a channel of open for the substrate and its analog.

Phtalate exposure during pregnancy impairs insulin signalling – at least in rats

Phtalates are present in many plastics as softener and thus ubiquitarily distributed. They have been regarded as endocrine disruptors that means they will bind to for example the estrogen receptor and trigger that molecule to start gene activation. That has been shown for quite some time.

What is new in the paper of Rajesh and Balasubramanian in the Journal of Endocrinology is the detail of the analysis: They have looked for glucose in di(ethylhexyl)phthalate (DEHP) treated mothers and their pubs and found elevated glucose, as well as glucose and insulin tolerance. The analysis went to the insuline receptor, the insulin receptor substrate, to the glucose transporter, to all the molecules thought involved in the regulation of insulin and glucose. But not the proteins alone, the RNAs were measured, even the methylation of the DNA was estimated. And the message is very clear: with DEHP exposure in utero you will encounter a disturbed metabolism throughout life.

While this is true for rats I might be another situation in humans, but would you risk your kids health on the assumption that man is not a rat?

Nicely done! Worth reading!