Steroids, diffusion and vesicle export

Steroid hormone are believed to cross membranes by diffusion. However, Winfried Hanke of the University of Karlruhe (Hanke,W. (1970). Hormone. Fortschr Zool 20. 318–380) had evidence that corticosterone was exported in vesicles. This discussion has relevance since steroid hormones in vesicles would be released when the release is triggered and not continously, while release by diffusion would be continously and regulated by the rate-limiting enzyme in the biosynthetic pathway. And the availability of steroid hormones is one very intruiging question in endocrinology.

An arcticle in Cell of this week demonstrates that ecdysone, that steroid hormone of insects is well released in vesicles. They analyze the machinery of SNARE’s (the proteins who will eventually upon a calcium trigger fuse to the cell membrane release the vesicle content to the outside of the cell) and the loading of ecdysone to the vesicle by the Abet ATP-binding cassette transporter in detail and very convincingly.

One wonders whether other steroids are loaded into vesicles similarily. And old story is to become exciting. Nice paper and very instructive images! Highly recommended!

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