Tag Archives: Regulation

The Proteasome adaptive response

While you are most probably familiar with proteasomes (otherwise it is barrel-like structure with heptameric symmetry of four ring, holes at both end through which ubiquitin targets proteins to be digested during which process it produces peptides of seven to nine amino acids which are either digested or loaded into the peptide pockets of histocompatibility proteins) you would not have thought about how proteasomes themselves are regulated.  A free article in Molecular Cell (dx.doi.org/10.1016/j.molcel.2014.06.017) demonstrates that a protein Adc17 is induced in stress and helps to maintain adequate numbers of proteasomes. A nice piece of work!